C. Tao

Unraveling the dynamic transcriptomic changes during the dimorphic transition of Talaromyces marneffei through time-course analysis

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

Analysis of clinical manifestations and risk factors of HIV-1 associated thrombocytopenia in a general teaching hospital in western China

This study examines the prevalence and risk factors of HIV-1 associated thrombocytopenia and its link to neuroinflammation in a hospital in western China.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

The high-resolution structure of cell membranes revealed by in situ cryo-electron tomography

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of human red blood cell membranes and their protein distribution.

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

B1L regulates lateral root development by exocytic vesicular trafficking-mediated polar auxin transport

This study shows B1L regulates lateral root development by enhancing polar auxin transport through exocytic vesicle trafficking and interaction with the exocyst complex in Arabidopsis.

Sofosbuvir Terminated RNA is More Resistant to SARS-CoV-2 Proofreader than RNA Terminated by Remdesivir

This study compares the resistance of SARS-CoV-2 RNA terminated by Sofosbuvir and Remdesivir to exonuclease proofreading, finding Sofosbuvir-terminated RNA more resistant.

A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses Causing SARS and COVID-19

This paper evaluates nucleotide analogues as inhibitors of SARS-CoV and SARS-CoV-2 RdRp, identifying those that terminate RNA synthesis and resist viral exonuclease activity.

Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase

The paper shows that the triphosphates of tenofovir and emtricitabine inhibit SARS-CoV-2 RNA-dependent RNA polymerase, suggesting potential use of DESCOVY and TRUVADA as PrEP for COVID-19.

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase

This study shows that three nucleotide analogues inhibit SARS-CoV-2 polymerase by being incorporated and blocking further RNA synthesis.

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

Enzymatic synthesis of gene-length single-stranded DNA

This paper develops an enzymatic method to synthesize long ssDNA sequences (>15 kb) with controlled nucleotide composition for therapeutic and imaging uses.