Author

P. A. Stewart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. L. Fridley· 2 shared O. E. Ospina· 2 shared A. C. Soupir· 1 shared A. E. Berglund· 1 shared A. R. Anderson· 1 shared B. Evernden· 1 shared B. J. Manley· 1 shared C. M. M. Segura· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

B. L. Fridley

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Author profile →

3 papers

Recent·Most cited

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

M. L. Khaled, Y. Ren, R. Kundalia, H. Alhaddad, Z. Chen, G. C. Wallace, B. Evernden, O. E. Ospina, M. Hall, M. Liu, L. N. F. Darville, V. Izumi, Y. A. Chen, S. Pilon-Thomas, P. A. Stewart, , I. Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

bioRxiv · Dec 18, 2023 · PreprintCancer Biology

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

M. Damaghi, J. West, M. Robertson-Tessi, L. Xu, M. C. Ferrall-Fairbanks, P. A. Stewart, E. A. Persi, B. L. Fridley, P. M. Altrock, R. Gatenby, p. A. Sims, A. R. Anderson, R. J. Gillies

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

bioRxiv · Apr 7, 2020Cancer Biology