O. Elemento

Multi-task learning predicts drug combination synergy in cells and in the clinic

This paper develops predictive models for drug synergy using multi-task learning, showing high accuracy in predicting synergistic drug pairs and their clinical relevance.

Generation of pulmonary neuro-endocrine cells and tumors resembling small cell lung cancers from human embryonic stem cells

The paper develops a model for studying small cell lung cancers by generating pulmonary neuro-endocrine cells and tumors from human embryonic stem cells through genetic manipulation.

Epigenetic analysis identifies factors driving racial disparity in prostate cancer

The paper analyzes epigenetic differences between African American and Caucasian prostate cancer patients to identify factors contributing to racial disparities in disease aggressiveness and outcomes.

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis

The paper shows that inhibiting glutaminolysis in cancer cells leads to lipid catabolism and autophagy, which promote survival, and that combined inhibition of both pathways can induce cell death.