Author

J. A. Spector

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

K. A. Brown· 3 shared O. Elemento· 3 shared C. Liu· 2 shared L. E. Dow· 2 shared P. Bhardwaj· 2 shared P. Piloco· 2 shared R. Bareja· 2 shared S. Oshchepkova· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

K. A. Brown

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

S. Liu, A. Benito-Martin, F. A. P. Vatter, S. Z. Hanif, C. Liu, P. Bhardwaj, P. Sethupathy, A. R. Farghli, P. Piloco, P. Paik, M. Mushannen, D. M. Otterburn, L. Cohen, R. Bareja, J. Krumsiek, , K. A. Brown

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

bioRxiv · Feb 8, 2023 · PreprintCancer Biology

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

P. Bhardwaj, N. M. Iyengar, H. Zahid, K. M. Carter, D. J. Byun, M.-H. Choi, Q. Sun, O. Savenkov, C. Louka, C. Liu, P. Piloco, M. Acosta, R. Bareja, O. Elemento, M. Foronda, , K. A. Brown

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

bioRxiv · Jul 29, 2022 · PreprintCancer Biology

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

C. C. Au, J. B. Furness, K. Britt, S. Oshchepkova, H. Ladumor, K. Y. Soo, B. Callaghan, C. Gerard, G. Inghirami, V. Mittal, Y. Wang, X.-Y. Huang, J. A. Spector, E. Andreopoulou, P. Zumbo, , K. A. Brown

This study shows unacylated ghrelin and its analog AZP531 inhibit breast cancer growth in 3D cultures and xenografts by suppressing MAPK signaling and inducing apoptosis.

bioRxiv · Jan 22, 2020 · PreprintCancer Biology

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

A. J. De Micheli, J. A. Spector, O. Elemento, B. D. Cosgrove

This study creates a single-cell transcriptomic atlas of human skeletal muscle, identifying two distinct muscle stem cell subpopulations with different transcriptional profiles and disease associations.

bioRxiv · Jan 21, 2020Cell Biology