Author

O. Petrenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. W. M. Van der Velden· 1 shared C. Liu· 1 shared H. V. Han· 1 shared K. Pham· 1 shared L. M. Ballou· 1 shared N. C. Reich· 1 shared N. Sivaram· 1 shared P. A. McLaughlin· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. W. M. Van der Velden

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2 papers

Recent·Most cited

STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

S. D'Amico, V. Kirillov, O. Petrenko, N. C. Reich

The paper identifies STAT3 as a genetic modifier of TGF-beta-induced EMT in KRAS mutant pancreatic cancer, showing its role in tumor maintenance and epithelial homeostasis.

eLife · Apr 4, 2024Peer-reviewedCancer Biology

PIK3CA in KrasG12D/Trp53R172H Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic Cancer

N. Sivaram, P. A. McLaughlin, H. V. Han, O. Petrenko, Y.-P. Jiang, L. M. Ballou, K. Pham, C. Liu, A. W. M. Van der Velden, R. Z. Lin

This study shows that PIK3CA-AKT signaling in pancreatic cancer cells limits T cell infiltration and tumor clearance by reducing MHC Class I and CD80 expression, suggesting it as a target for immunotherapy.

bioRxiv · Jan 15, 2019 · PreprintCancer Biology