Author

R. Z. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. V. Han· 2 shared Y.-P. Jiang· 2 shared A. Van Der Velden· 1 shared A. W. M. Van der Velden· 1 shared B. Rosati· 1 shared C. Liu· 1 shared K. Lu· 1 shared K. Pham· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

H. V. Han

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2 papers

Recent·Most cited

Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

H. V. Han, R. Efem, B. Rosati, K. Lu, S. Maimouni, Y.-P. Jiang, V. Montoya, A. Van Der Velden, W.-X. Zong, R. Z. Lin

This study identifies Pccb as a regulator of anti-tumor T cell activity in pancreatic cancer, showing that its deletion impairs T cell function and that PD-L1/PD1 blockade can restore T cell activity.

bioRxiv · Jul 24, 2023Cancer Biology

PIK3CA in KrasG12D/Trp53R172H Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic Cancer

N. Sivaram, P. A. McLaughlin, H. V. Han, O. Petrenko, Y.-P. Jiang, L. M. Ballou, K. Pham, C. Liu, A. W. M. Van der Velden, R. Z. Lin

This study shows that PIK3CA-AKT signaling in pancreatic cancer cells limits T cell infiltration and tumor clearance by reducing MHC Class I and CD80 expression, suggesting it as a target for immunotherapy.

bioRxiv · Jan 15, 2019 · PreprintCancer Biology