Uncovering the Interleukin-12 Pharmacokinetic Desensitization Mechanism and Its Consequences with Mathematical Modeling
J. DeBonis, O. Veiseh, O. A. Igoshin
This paper develops a mathematical model to explain IL-12 pharmacokinetic desensitization, showing that reduced bioavailability, not increased clearance, best explains clinical data.
CPT: Pharmacometrics & Systems Pharmacology · Oct 16, 2024Peer-reviewedBioengineering