Author

B. Mahata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:human· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Research Focus:protein folding & dynamics· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

J. Pramanik· 5 shared S. A. Teichmann· 4 shared G. Kar· 3 shared X. Chen· 3 shared A. Riedel· 2 shared A.-C. Gavin· 2 shared D. A. Brenner· 2 shared I. B. Hilton· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersImmunology

J. Pramanik

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Multiomic Screening Unravels the Immunometabolic Signatures and Drug Targets of Age-Related Macular Degeneration

X. cui, Q. Zhao, B. Mahata, D. Wen, P. Yu-Wai-Man, X. Li

This study uses multiomic methods to identify immunometabolic pathways and drug targets in AMD, highlighting key genes and pathways involved in disease progression and potential therapeutic interventions.

bioRxiv · May 7, 2024 · PreprintImmunology

Persistent tailoring of MSC activation through genetic priming

M. A. Beauregard, G. C. Bedford, D. A. Brenner, L. D. Sanchez Solis, T. Nishiguchi, Abhimanyu, S. Carrero Longlax, B. Mahata, O. Veiseh, P. L. Wenzel, A. R. DiNardo, I. B. Hilton, M. R. Diehl

This paper introduces a genetic priming method using IRF1 to sustainably enhance MSC potency and suppress immunogenicity compared to biochemical priming.

bioRxiv · Feb 1, 2024Bioengineering

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

S. Roy, S. Roy, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. A. Teichmann

The paper identifies pregnenolone targets and their binding conformations in Th2 cells using chemoproteomics and molecular dynamics simulations.

bioRxiv · May 23, 2023Immunology

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

B. Mahata, A. Cabrera, D. A. Brenner, R. S. Guerra-Resendez, J. Li, J. Goell, K. Wang, Y. Guo, M. Escobar, A. K. Parthasarathy, H. Szadowski, G. Bedford, D. Reed, I. B. Hilton

This paper develops compact human mechanosensitive TADs for synthetic transcriptional control, showing they are potent, versatile, and well-tolerated in primary cells.

bioRxiv · Mar 21, 2022Bioengineering

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

B. Mahata, J. Pramanik, L. v. d. Weyden, K. Polanski, G. Kar, A. Riedel, X. Chen, N. A. Fonseca, K. Kundu, L. S. Campos, E. Ryder, G. Duddy, I. Walczak, K. Okkenhaug, D. J. Adams, , S. A. Teichmann

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

bioRxiv · Jun 14, 2020Immunology

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

S. Roy, J. Sipthorp, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. V. Ley, S. Teichmann

The paper maps pregnenolone interactomes in cancer and immune cells using chemical biology and chemoproteomics to identify proteins involved in its trafficking and non-genomic actions.

bioRxiv · Oct 16, 2019Biochemistry

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

S. Davidson, M. Efremova, A. Riedel, B. Mahata, J. Pramanik, J. Huuhtanen, G. Kar, R. Vento-Tormo, T. Hagai, X. Chen, M. A. Haniffa, J. D. Shields, S. A. Teichmann

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

bioRxiv · Nov 9, 2018 · PreprintCancer Biology

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

J. Pramanik, X. Chen, G. Kar, T. Gomes, J. Henriksson, Z. Miao, K. Natarajan, A. N. J. McKenzie, B. Mahata, S. A. Teichmann

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

bioRxiv · Dec 15, 2017Cell Biology