Author

T. Nishiguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. R. DiNardo· 3 shared A. Kay· 2 shared A. M. Mandalakas· 2 shared C. Coarfa· 2 shared G. Makedonas· 2 shared G. Maphalala· 2 shared G. Mtetwa· 2 shared K. Rajapakshe· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

A. R. DiNardo

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Author profile →

3 papers

Recent·Most cited

Persistent tailoring of MSC activation through genetic priming

M. A. Beauregard, G. C. Bedford, D. A. Brenner, L. D. Sanchez Solis, T. Nishiguchi, Abhimanyu, S. Carrero Longlax, B. Mahata, O. Veiseh, P. L. Wenzel, A. R. DiNardo, I. B. Hilton, M. R. Diehl

This paper introduces a genetic priming method using IRF1 to sustainably enhance MSC potency and suppress immunogenicity compared to biochemical priming.

bioRxiv · Feb 1, 2024Bioengineering

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

A. R. DiNardo, K. Rajapakshe, T. Nishiguchi, G. Mtetwa, Q. Dlamini, J. Kahari, S. Mahapatra, A. Kay, G. Maphalala, E. Mace, S. L. Grimm, G. Makedonas, J. D. Cirillo, M. G. Netea, R. van Crevel, , A. M. Mandalakas

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

bioRxiv · Oct 16, 2019 · PreprintImmunology

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

A. R. DiNardo, T. Nishiguchi, E. M. Mace, K. Rajapakshe, G. Mtetwa, A. Kay, G. Maphalala, W. E. Secor, R. A. Mejia, C. Coarfa, K. N. Bhalla, E. A. Graviss, J. S. Orange, G. Makedonas, A. M. Mandalakas

This study shows helminth infections cause long-term DNA methylation and immune changes that impair TB-specific immune responses.

bioRxiv · Jan 27, 2018Immunology