Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
M. M. Clemens, S. Kennon-McGill, J. H. Vazquez, O. W. Stephens, E. A. Peterson, D. J. Johann, F. D. Allard, E. U. Yee, S. S. McCullough, L. P. James, B. N. Finck, M. R. McGill
This study shows exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic IL-6 signaling through inter-organ crosstalk, but does not enhance liver regeneration.
bioRxiv · Dec 22, 2020Pharmacology & Toxicology