Author

P. A. Cotter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 5 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

R. M. Johnson· 4 shared Z. M. Nash· 3 shared A. I. Perault· 2 shared L. S. McKay· 2 shared M. A. Sobran· 2 shared M. R. Dedloff· 2 shared A. B. Ocasio· 1 shared A. R. Spandrio· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

R. M. Johnson

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8 papers

Recent·Most cited

Cytochrome oxidase requirements in Bordetella reveal insights into evolution towards life in the mammalian respiratory tract

L. S. McKay, A. R. Spandrio, R. M. Johnson, M. A. Sobran, S. Marlatt, K. B. Mote, M. R. Dedloff, Z. M. Nash, S. M. Julio, P. A. Cotter

This study investigates the role of cytochrome oxidases in Bordetella species, finding that three specific oxidases are sufficient for respiratory infection in mice.

bioRxiv · Feb 29, 2024 · PreprintMicrobiology

Bordetella Filamentous hemagglutinin (FhaB) and Adenylyl cyclase toxin (ACT) interactions on the bacterial surface are consistent with FhaB-mediated delivery of ACT to phagocytic cells

Z. M. Nash, C. S. Inatsuka, P. A. Cotter, R. M. Johnson

The paper shows FhaB binds ACT on the bacterial surface, enabling its delivery to phagocytic cells via CR3 receptor interaction.

bioRxiv · Sep 6, 2023 · PreprintMicrobiology

An IS-mediated, RecA-dependent, bet-hedging strategy in Burkholderia thailandensis

L. C. Lowrey, L. A. Kent, B. M. Rios, A. B. Ocasio, P. A. Cotter

The paper identifies a phase variation system in Burkholderia thailandensis that generates phenotypically heterogeneous populations through IS-mediated, RecA-dependent duplication and resolution of a chromosomal region.

bioRxiv · Nov 9, 2022Microbiology

Phosphorylation chemistry of the Bordetella PlrSR TCS and its contribution to bacterial persistence in the lower respiratory tract

S. A. Barr, E. N. Kennedy, L. S. McKay, R. M. Johnson, R. J. Ohr, P. A. Cotter, R. B. Bourret

This study characterizes the phosphorylation chemistry of the Bordetella PlrSR two-component system and shows its role in bacterial persistence in the mouse lung.

bioRxiv · Oct 6, 2022Microbiology

The Burkholderia cenocepacia type VI secretion system effector TecA is a virulence factor during lung infection

N. A. Loeven, A. I. Perault, P. A. Cotter, C. A. Hodges, J. D. Schwartzman, T. H. Hampton, J. B. Bliska

This paper demonstrates that TecA, a type VI secretion system effector of Burkholderia cenocepacia, acts as a virulence factor by exacerbating lung inflammation, weight loss, and lethality in a CF mouse model.

bioRxiv · Jul 13, 2021Microbiology

DegP initiates regulated processing of filamentous hemagglutinin in Bordetella bronchiseptica

R. M. Johnson, Z. M. Nash, M. R. Dedloff, J. C. Shook, P. A. Cotter

This study identifies DegP as the protease initiating FhaB processing in Bordetella bronchiseptica, showing it removes a C-terminal inhibitory segment to enable CtpA-mediated degradation.

bioRxiv · May 21, 2021Microbiology

Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex

A. I. Perault, C. E. Chandler, D. A. Rasko, R. K. Ernst, M. C. Wolfgang, P. A. Cotter

The paper shows that Pa isolates from older CF patients are outcompeted by Bcc strains due to T6SS-abrogating mutations, increasing susceptibility to Bcc superinfection.

Cell Host & Microbe · Oct 1, 2020Peer-reviewedMicrobiology

The BvgS PAS domain: an independent sensory perception module in the Bordetella BvgAS phosphorelay

P. A. Cotter, M. A. Sobran

This paper shows the BvgS PAS domain functions as an independent signal perception module in Bordetella, essential for inactivating BvgS in the absence of PlrS and regulating kinase activity.

bioRxiv · Apr 23, 2019Microbiology