T. H. Hampton

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Analysis of Pseudomonas aeruginosa transcription in an ex vivo cystic fibrosis sputum model identifies metal restriction as a gene expression stimulus

The paper analyzes Pseudomonas aeruginosa gene expression in CF sputum and identifies metal restriction as a key driver of gene expression variation across donors.

An In Vitro Medium for Modeling Gut Dysbiosis Associated with Cystic Fibrosis

This paper develops a novel in vitro culture medium, CF-MiPro, that mimics the CF gut environment and alters non-CF microbiomes to resemble CF-like profiles.

Predicting Clinical Outcomes in Infants With Cystic Fibrosis From Stool Microbiota using Random Forest Algorithms

This paper uses random forest algorithms to predict clinical outcomes in children with cystic fibrosis based on stool microbiota composition.

Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

This study develops a polymicrobial biofilm model of the CF lung to investigate community-specific antimicrobial resistance and identifies LasR loss-of-function as a driver of tobramycin tolerance through increased phenazine production.

Development of the Intestinal Microbiome in Cystic Fibrosis in Early Life

This study tracks the development of the gut microbiome in children with cystic fibrosis from birth to age 4, finding persistent dysbiosis and early signs of inflammatory bowel disease-associated microbiota.

The Burkholderia cenocepacia type VI secretion system effector TecA is a virulence factor during lung infection

This paper demonstrates that TecA, a type VI secretion system effector of Burkholderia cenocepacia, acts as a virulence factor by exacerbating lung inflammation, weight loss, and lethality in a CF mouse model.

Mild CF Lung Disease is Associated with Bacterial Community Stability

The paper identifies five bacterial community types in CF patients and finds that community instability is linked to worse lung function outcomes.

Availability of Zinc Impacts Interactions Between Streptococcus sanguinis and Pseudomonas aeruginosa in Co-culture

This study shows that zinc availability affects the growth dynamics between Streptococcus sanguinis and Pseudomonas aeruginosa in co-culture, with lower zinc levels favoring Streptococcus and higher levels favoring Pseudomonas.