Lactate regulation of activation in CD8+ T cells
L. Barbieri, P. Velica, P. A. Gameiro, P. P. Cunha, I. P. Foskolou, D. Bargiela, H. Rundqvist, R. Johnson
This study shows lactate can displace glucose as a carbon source for activated CD8+ T cells and alters their transcriptome, affecting effector differentiation markers.
bioRxiv · Dec 14, 2021 · PreprintImmunology