Author

P. A. Sigala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Organism:plant (other)· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. E. Garcia-Guerrero· 2 shared A. M. Blackwell· 2 shared M. Okada· 2 shared R. G. Marvin· 2 shared S.-a. Nalder· 2 shared Y. Jami-Alahmadi· 2 shared A. Mixon· 1 shared C. P. Hill· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

A. E. Garcia-Guerrero

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5 papers

Recent·Most cited

Biogenesis of cytochromes c and c1 in the electron transport chain of malaria parasites

A. E. Garcia-Guerrero, R. G. Marvin, A. M. Blackwell, P. A. Sigala

This study investigates the role of HCCS and HCC1S in cytochrome c and c1 biogenesis in malaria parasites, revealing their distinct specificities and essential functions in the mitochondrial electron transport chain.

bioRxiv · Feb 1, 2024Microbiology

Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites

T. J. Espino-Sanchez, H. Wienkers, R. G. Marvin, S.-a. Nalder, A. E. Garcia-Guerrero, P. E. VanNatta, Y. Jami-Alahmadi, A. M. Blackwell, F. G. Whitby, J. A. Wohlschlegel, M. T. Kieber-Emmons, C. P. Hill, P. A. Sigala

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

bioRxiv · Jan 23, 2023Microbiology

Critical Role for Isoprenoids in Apicoplast Biogenesis by Malaria Parasites

M. Okada, K. Rajaram, R. P. Swift, A. Mixon, J. A. Maschek, S. T. Prigge, P. A. Sigala

This study identifies a critical role for isoprenoids in apicoplast biogenesis in malaria parasites, showing that IPP and polyprenols are essential for apicoplast membrane fluidity and inheritance.

bioRxiv · Aug 19, 2021Microbiology

Divergent Acyl Carrier Protein Decouples Mitochondrial Fe-S Cluster Biogenesis from Fatty Acid Synthesis in Malaria Parasites

S. Falekun, J. Sepulveda, Y. Jami-Alahmadi, H. Park, J. Wohlschlegel, P. A. Sigala

This paper identifies a divergent acyl carrier protein in Plasmodium that couples mitochondrial Fe-S cluster biogenesis to the electron transport chain, independent of fatty acid synthesis.

bioRxiv · Apr 13, 2021Microbiology

Doxycycline has Distinct Apicoplast-Specific Mechanisms of Antimalarial Activity

M. Okada, P. Guo, S.-a. Nalder, P. A. Sigala

This study shows doxycycline kills malaria parasites via apicoplast-specific mechanisms at high concentrations, with distinct metal-dependent and delayed-death effects in different cycles.

bioRxiv · Jun 11, 2020Microbiology