Author

P. Brian Hardy

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Brandon NovyiD· 2 shared Devan J. ShelliD· 2 shared Eric M. MerteniD· 2 shared Ivanna ZhilinskayaiD· 2 shared James WellnitziD· 2 shared Kenneth H. PearceiD· 2 shared Konstantin I. PopoviD· 2 shared Shu-Hang LiniD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Brandon NovyORCID

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Author profile →

2 papers

Recent·Most cited

Open-Source DNA-Encoded Library Package for Design, Decoding, and Analysis: DELi

James Wellnitz, Brandon Novy, Shu-Hang Lin, Travis Maxfield, Matthew Axtman, Tina M. Leisner, Eric M. Merten, Ivanna Zhilinskaya, Devan J. Shell, Kellyn M. Schroeder, Jacqueline L. Norris-Drouin, P. Brian Hardy, Kenneth H. Pearce, Konstantin I. Popov

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

Journal of Cheminformatics · Sep 4, 2026Peer-reviewedBioinformatics

Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs

Brandon Novy, Shu-Hang Lin, Devan J. Shell, Travis Maxfield, Eric M. Merten, Ivanna Zhilinskaya, James Wellnitz, Shiva Krishna Reddy Guduru, P. Brian Hardy, Kenneth H. Pearce, Konstantin I. Popov

This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.

bioRxiv · Sep 30, 2025 · PreprintBiophysics