Author

Matthew Axtman

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Kenneth H. PearceiD· 2 shared Benjamin I. Morris· 1 shared Brandon NovyiD· 1 shared Brian P. ConloniD· 1 shared Brian P. HardyiD· 1 shared Devan J. ShelliD· 1 shared Eric M. MerteniD· 1 shared Ivanna ZhilinskayaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioinformatics

Kenneth H. PearceORCID

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2 papers

Recent·Most cited

Open-Source DNA-Encoded Library Package for Design, Decoding, and Analysis: DELi

James Wellnitz, Brandon Novy, Shu-Hang Lin, Travis Maxfield, Matthew Axtman, Tina M. Leisner, Eric M. Merten, Ivanna Zhilinskaya, Devan J. Shell, Kellyn M. Schroeder, Jacqueline L. Norris-Drouin, P. Brian Hardy, Kenneth H. Pearce, Konstantin I. Popov

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

Journal of Cheminformatics · Sep 4, 2026Peer-reviewedBioinformatics

A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics

Kuan‐Yi Lu, Xiangbo Yang, Matthew J. G. Eldridge, Rongfeng Sun, Rachel T. Giorgio, Benjamin I. Morris, Nikki J. Wagner, Brian P. Hardy, Matthew Axtman, Sarah E. Rowe, Xiaodong Wang, Vance G. Fowler, Qingyun Liu, Sophie Hélaine, Kenneth H. Pearce, Brian P. Conlon

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

Nature Microbiology · Oct 10, 2025Peer-reviewedMicrobiology