Author

P. C. Matthews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

K. Jeffery· 4 shared A. L. McNaughton· 3 shared J. Mokaya· 3 shared A. Ansari· 2 shared A. S. Walker· 2 shared A. Vaughan· 2 shared C. S. Akiror· 2 shared D. Foster· 2 shared

Activity by Year

2017-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

K. Jeffery

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations

J. Mokaya, T. I. Vasylyeva, E. Barnes, M. A. Ansari, O. G. Pybus, P. C. Matthews

This study analyzes the global prevalence and phylogeny of HBV drug and vaccine resistance mutations, finding high prevalence in genotype C and evidence of independent emergence of resistance mutations.

bioRxiv · Oct 7, 2020Evolutionary Biology

Analysis of genomic-length HBV sequences to determine genotype and subgenotype reference sequences

A. L. McNaughton, P. Revill, M. Littlejohn, P. C. Matthews, M. A. Ansari

The paper generates updated HBV genotype and subgenotype reference sequences using phylogenetic analysis of genomic-length sequences from public databases.

bioRxiv · Nov 8, 2019Microbiology

Metagenomic Nanopore sequencing of influenza virus direct from clinical respiratory samples

K. Lewandowski, Y. Xu, S. T. Pullan, D. Foster, N. D. Sanderson, A. Vaughan, M. Morgan, N. Bright, J. Kavanagh, R. T. Vipond, M. W. Carroll, A. C. Marriott, K. E. Gooch, M. Andersson, K. Jeffery, , P. C. Matthews

This study uses metagenomic Nanopore sequencing to detect influenza virus in clinical respiratory samples, achieving high sensitivity and complete genome sequencing.

bioRxiv · Jun 19, 2019Microbiology

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

L. O. Downs, D. Smith, S. F. Lumley, M. Patel, A. L. McNaughton, J. Mokaya, A. Ansari, H. Salih, K. A. Varnai, O. Freeman, S. Cripps, J. Phillips, J. Collier, K. Woods, K. Channon, , P. C. Matthews

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

bioRxiv · Mar 26, 2019Microbiology

Nanopore metagenomic sequencing of full length human metapneumovirus (HMPV) within a unique sub-lineage

Y. Xu, K. Lewandowski, S. Lumley, N. D. Sanderson, A. Vaughan, R. T. Vipond, M. W. Carroll, K. Jeffery, D. Foster, A. S. Walker, T. E. A. Peto, D. W. Crook, S. T. Pullan, P. C. Matthews

This study uses Nanopore metagenomic sequencing to directly sequence the full-length HMPV genome from a UK patient, identifying a unique genetic group and demonstrating the utility of Nanopore for clinical diagnosis.

bioRxiv · Dec 17, 2018 · PreprintMicrobiology

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

A. McNaughton, J. Lourenco, L. Hattingh, E. Adland, S. Daniels, A. van Zyl, C. S. Akiror, S. Wareing, K. Jeffery, A. Ansari, P. Klenerman, P. Goulder, S. Gupta, P. Jooste, P. C. Matthews

This study evaluates HBV vaccination and PMTCT as tools for elimination in HIV-coinfected populations using a clinical cohort and dynamic model, showing potential for significant public health impact by 2030.

bioRxiv · Sep 24, 2018Microbiology

Hepatitis B Virus Infection as a Neglected Tropical Disease

G. A. O'Hara, A. L. McNaughton, T. Maponga, P. Jooste, P. Ocama, R. Chilengi, J. Mokaya, M. I. Liyayi, T. Wachira, D. Gikungi, L. Burbridge, D. O'Donnell, C. S. Akiror, D. Sloan, J. Torimiro, , P. C. Matthews

The paper examines HBV infection through the lens of neglected tropical diseases and highlights challenges in elimination efforts.

bioRxiv · Jul 18, 2017Microbiology