P. Dasmeh

Neutral Drift and Threshold Selection Promote Phenotypic Variation

The paper shows neutral drift and threshold selection generate phenotypic variation in antibiotic resistance genes without adaptation.

Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

This study shows phosphorylation sites prevent liquid-solid transitions in FUS condensates by reducing β-sheet propensity and stabilizing liquid-like states.

Rapid evolutionary change in trait correlations of a single protein

This study shows that trait correlations of a single protein can evolve rapidly through mutation and selection, driven by changes in protein foldability.

The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins

The paper investigates the evolutionary conservation of multivalency length scale in fungal and vertebrate phase-separating proteins, finding it is maintained despite variation in multivalency.

Natural selection has preserved and enhanced the phase-separation properties of FUS during 160 million years of mammalian evolution

The paper examines the evolutionary conservation of FUS's phase-separation properties, finding stabilizing and positive selection acting on its prion-like domain.

IFNβ and TNFα cooperate to induce a STAT1-independent antiviral and immunoregulatory program via non-canonical STAT2 and IRF9 pathway

The paper shows that IFNβ and TNFα together induce a STAT1-independent antiviral program via non-canonical STAT2 and IRF9 pathways.

Multi-step regulation of transcription kinetics explains the non-linear relation between RNA polymerase II density and mRNA expression in Dosage Compensation

Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli

The paper quantifies epistasis across 2,382 E. coli genes using orthologs and finds stronger epistasis in highly expressed genes, explained by protein unfolding models.