Author

N. Grandvaux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

E. Caron· 4 shared A. Fortin· 3 shared E. Mukawera· 2 shared N. Zamorano Cuervo· 2 shared A. A. Kelvin· 1 shared A. C. Robitaille· 1 shared A. Gelinas· 1 shared A. N. Harrison· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersImmunology

E. Caron

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

M. M. A. Rahim, B. Parsons, E. L. Price, P. D. Slaine, B. L. Chilvers, G. S. Seaton, A. Wight, S. Dey, S. L. Grandy, L. E. Anderson, N. Zamorano Cuervo, N. Grandvaux, M. M. Gaglia, A. A. Kelvin, D. A. Khaperskyy, , A. P. Makrigiannis

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.

Journal of Virology · Jun 16, 2020Peer-reviewedMicrobiology

Pinpointing of cysteine oxidation sites in vivo by high-resolution proteomics reveals mechanism of redox-dependent inhibition of STING

N. Zamorano Cuervo, A. Fortin, E. Caron, S. Chartier, N. Grandvaux

This study identifies thousands of reversible Cys oxidation sites in vivo using a bioswitch method and mass spectrometry, revealing redox-dependent inhibition of STING through Cys206 oxidation.

bioRxiv · Mar 25, 2020Immunology

IFNβ and TNFα cooperate to induce a STAT1-independent antiviral and immunoregulatory program via non-canonical STAT2 and IRF9 pathway

M. Mariani, P. Dasmeh, A. Fortin, E. Caron, M. Kalamujic, A. N. Harrison, D. M. Kasumba, S. Cervantes-Ortiz, E. Mukawera, A. W. R. Serohijos, N. Grandvaux

The paper shows that IFNβ and TNFα together induce a STAT1-independent antiviral program via non-canonical STAT2 and IRF9 pathways.

bioRxiv · Nov 7, 2018 · PreprintImmunology

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection

A. C. Robitaille, E. Caron, N. Zucchini, E. Mukawera, D. Adam, M. K. Mariani, A. Gelinas, A. Fortin, E. Brochiero, N. Grandvaux

This study shows DUSP1 promotes apoptosis and inhibits cell migration during RSV and SeV infection but does not affect JIP1-protected cytokine responses.

bioRxiv · Nov 26, 2017Microbiology

Structural Basis Of STAT2 Recognition By IRF9 Reveals Molecular Insights Into ISGF3 Function

S. Rengachari, S. Groiss, J. Devos, E. Caron, N. Grandvaux, D. Panne

The paper determines the crystal structures of IRF9-IAD and its complex with STAT2-CCD, revealing structural basis for ISGF3 formation and ISG regulation.

bioRxiv · Apr 28, 2017Biophysics