A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
T. F. dos Reis, P. A. de Castro, R. Bastos, C. F. Pinzan, P. F. Souza, S. Ackloo, M. A. Hossain, D. Drewry, S. Alkhazraji, A. Ibrahim, H. Jo, W. F. deGrado, G. Goldman
This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.
bioRxiv · Sep 28, 2022 · PreprintMicrobiology