S. Alkhazraji

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

Efficacy of an oral lipid nanocrystal (LNC) formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis

This study compares the efficacy of oral MAT2203 to intravenous LAMB in a neutropenic mouse model of mucormycosis, finding MAT2203 as effective in survival and fungal burden reduction.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

Monoclonal IgM antibodies raised against Candida albicans Hyr1 provide cross-kingdom protection against Gram negative bacteria

The paper shows monoclonal antibodies against Candida albicans Hyr1 protect against Gram-negative bacterial infections.