Author

G. Goldman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:fungi (other)· 5 Assay:whole-genome sequencing· 5 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Rokas· 4 shared J. L. Steenwyk· 4 shared M. E. Mead· 4 shared P. A. de Castro· 3 shared A. Damasio· 2 shared C. F. Pinzan· 2 shared C. Valero· 2 shared H. A. Raja· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersEvolutionary Biology

A. Rokas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Deacetylation by sirtuins is important for Aspergillus fumigatus pathogenesis and virulence

N. S. Wassano, G. B. da Silva, A. H. Reis, J. A. Gerhardt, E. P. Antoniel, D. Y. Akiyama, C. P. Rezende, L. X. Neves, E. Vasconcelos, F. L. Figueiredo, F. Almeida, P. A. de Castro, C. F. Pinzan, G. Goldman, A. F. Paes Leme, , A. Damasio

This study shows that sirtuins in Aspergillus fumigatus are important for virulence and pathogenesis, with AfSirE deletion reducing virulence and altering protein acetylation and gene expression.

bioRxiv · Sep 25, 2023 · PreprintMicrobiology

Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen

J. L. Steenwyk, S. L. Knowles, R. Bastos, C. Balamurugan, D. Rinker, M. E. Mead, C. D. Roberts, H. A. Raja, Y. Li, A. C. Colabardini, P. A. Castro, T. F. Reis, D. Canovas, R. L. Sanchez, K. Lagrou, , A. Rokas

This study identifies and characterizes the cryptic fungal pathogen Aspergillus latus, revealing its hybrid origin and developing genomic and phenotypic markers for accurate diagnosis.

bioRxiv · Jul 3, 2023 · PreprintEvolutionary Biology

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

T. F. dos Reis, P. A. de Castro, R. Bastos, C. F. Pinzan, P. F. Souza, S. Ackloo, M. A. Hossain, D. Drewry, S. Alkhazraji, A. Ibrahim, H. Jo, W. F. deGrado, G. Goldman

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

bioRxiv · Sep 28, 2022 · PreprintMicrobiology

Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in Aspergillus fumigatus

N. van Rhijn, S. Hemmings, I. S. R. Storer, C. Valero, H. Alshammri, G. Goldman, F. Gsaller, J. Amich, M. J. Bromley

This study identifies antagonism between triazoles and olorofim in Aspergillus fumigatus due to transcriptional regulation of pyrimidine and ergosterol pathways, revealing cross-resistance mechanisms.

bioRxiv · Nov 18, 2021Microbiology

Extensive sequence divergence of non-coding regions between Aspergillus fumigatus, a major fungal pathogen of humans, and its relatives

A. Brown, M. E. Mead, J. L. Steenwyk, G. Goldman, A. Rokas

The paper identifies extensive non-coding sequence divergence in A. fumigatus compared to related species, highlighting its potential role in virulence.

bioRxiv · Oct 26, 2021 · PreprintEvolutionary Biology

An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related Aspergillus fungi

M. E. Mead, J. L. Steenwyk, L. P. Silva, P. A. de Castro, N. Saeed, F. Hillmann, G. Goldman, A. Rokas

This study uses comparative genomics to identify conserved and species-specific genetic elements related to pathogenicity in Aspergillus fungi, revealing evolutionary patterns linked to human disease.

bioRxiv · Mar 1, 2021Evolutionary Biology

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

J. L. Steenwyk, M. E. Mead, P. A. Castro, C. Valero, A. Damasio, R. A. C. Santos, A. L. LaBella, Y. Li, S. L. Knowles, H. A. Raja, N. H. Oberlies, X. Zhou, O. A. Cornely, F. Fuchs, P. Koehler, , A. Rokas

The paper analyzes the genomes and phenotypes of four Aspergillus fumigatus isolates from COVID-19 patients, finding minor genomic differences and variable virulence traits.

bioRxiv · Nov 6, 2020Microbiology