P. A. de Castro

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

Strain heterogeneity in a non-pathogenic fungus highlights factors contributing to virulence

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

Milteforan, a promising veterinary commercial product against feline sporotrichosis

The paper shows milteforan, a veterinary product containing miltefosine, is effective against sporotrichosis caused by S. brasiliensis and S. schenckii in vitro and in infected cells.

Deacetylation by sirtuins is important for Aspergillus fumigatus pathogenesis and virulence

This study shows that sirtuins in Aspergillus fumigatus are important for virulence and pathogenesis, with AfSirE deletion reducing virulence and altering protein acetylation and gene expression.

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

Secondary metabolites produced during Aspergillus fumigatus and Pseudomonas aeruginosa biofilm formation

This study identifies secondary metabolites produced by Aspergillus fumigatus and Pseudomonas aeruginosa during biofilm formation in normoxia and hypoxia, revealing differences in metabolite secretion between monoculture and co-culture.

Every single conidium in Aspergillus fumigatus caspofungin tolerant strains are intrinsically caspofungin tolerant

The paper investigates whether caspofungin tolerance in Aspergillus fumigatus is a population-level or individual-level trait by testing conidia from clinical isolates.

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

This study identifies conserved transcription factors and genes involved in gliotoxin protection in Aspergillus species through RNA-sequencing and deletion screening.

Aspergillus fumigatus acetate utilisation impacts virulence traits and pathogenicity

This paper investigates how acetate utilization by Aspergillus fumigatus affects virulence traits and pathogenicity, showing its role in secondary metabolite secretion, cell wall composition, and in vivo virulence.

An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related Aspergillus fungi

This study uses comparative genomics to identify conserved and species-specific genetic elements related to pathogenicity in Aspergillus fungi, revealing evolutionary patterns linked to human disease.

Aspergillus fumigatus G-protein coupled receptors GprM and GprJ are important for the regulation of the cell wall integrity pathway, secondary metabolite production, and virulence

This paper investigates the role of GprM and GprJ GPCRs in A. fumigatus, showing they regulate cell wall integrity, secondary metabolite production, and virulence.