Author

A. Spitaleri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metagenomics· 1

Frequent Co-Authors

C. Utpatel· 2 shared d. Cirillo· 2 shared D. M. Cirillo· 2 shared S. Niemann· 2 shared A. Barbova· 1 shared A. Cabibbe· 1 shared A. Cavallero· 1 shared A. Crisanti· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

C. Utpatel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Endolysin B: A new archetype in M. tuberculosis treatment

A. Griego, B. Antinori, A. Spitaleri, I. Muzzolini, S. Muzzioli, L. Calo, G. Moschetti, M. Genta, E. Scarpa, V. De Matteis, R. Miggiano, S. Ricagno, L. Rizzello

This study demonstrates that Ms6LysB can impair M. tuberculosis growth and retain lytic properties when internalized by macrophages, suggesting its potential as a new therapeutic strategy.

bioRxiv · Dec 5, 2023 · PreprintMicrobiology

Genetic barriers more than ecological adaptations shaped Serratia marcescens diversity

L. Sterzi, R. Nodari, F. Di Marco, M. L. Ferrando, F. Saluzzo, A. Spitaleri, H. Allahverdi, S. Papaleo, S. Panelli, S. G. Rimoldi, G. Batisti Biffignandi, M. Corbella, A. Cavallero, P. Prati, C. Farina, , F. Comandatore

This study shows genetic isolation, particularly through R-M systems, shaped Serratia marcescens diversity more than ecological adaptations.

bioRxiv · Jul 14, 2023 · PreprintEvolutionary Biology

Rapid longitudinal SARS-CoV-2 intra-host emergence of novel haplotypes regardless of immune deficiencies

L. Manuto, M. Grazioli, A. Spitaleri, P. Fontana, L. Bianco, L. Bertolotti, M. Bado, G. Mazzotti, F. Bianca, F. Onelia, G. Lorenzin, F. Simeoni, D. Lazarevic, E. Franchin, C. Del Vecchio, , S. Toppo

The paper analyzes SARS-CoV-2 genomic data from a quarantined Italian town, showing rapid intra-host emergence of novel viral haplotypes within two weeks, regardless of immune status or symptoms.

bioRxiv · Dec 22, 2021 · PreprintEvolutionary Biology

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach

L. Sonnenkalb, J. Carter, A. Spitaleri, Z. Iqbal, M. Hunt, K. Malone, C. Utpatel, D. M. Cirillo, C. Rodrigues, K. S. Nilgiriwala, the CRyPTIC Consortium, P. W. Fowler, M. Merker, S. Niemann

This study identifies 230 genomic variants associated with resistance to bedaquiline and clofazimine in tuberculosis using experimental evolution, genome sequencing, and structural modeling.

bioRxiv · Mar 19, 2021Microbiology

Characterization of genomic variants associated with resistance to bedaquiline and delamanid in naïve Mycobacterium tuberculosis clinical strains

S. Battaglia, A. Spitaleri, A. Cabibbe, C. Meehan, C. Utpatel, N. Ismail, S. Tahseen, A. Skrahina, N. Alikhanova, K. S. Mostofa, A. Barbova, S. Niemann, R. Groenheit, A. Dean, M. Zignol, , D. Cirillo

This study identifies genetic mutations associated with resistance to bedaquiline and delamanid in Mycobacterium tuberculosis strains using whole genome sequencing and in silico analysis.

bioRxiv · May 27, 2020Microbiology