Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
G. Du, L. B. Healy, L. David, C. Walker, P. Fontana, Y. Dong, P. Devant, R. Puthenveetil, S. B. Ficarro, A. Banerjee, J. C. Kagan, J. Lieberman, H. Wu
This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.
bioRxiv · Mar 7, 2023Immunology
Y.-D. Li, M. W. Ma, M. M. Hassan, M. Hunkeler, M. Teng, K. Puvar, R. Lumpkin, B. Sandoval, C. Y. Jin, S. B. Ficarro, M. Y. Wang, S. Xu, B. J. Groendyke, L. H. Sigua, I. Tavares, , B. L. Ebert
This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.
bioRxiv · Feb 14, 2023Biochemistry
M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray
This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.
bioRxiv · May 10, 2022Cancer Biology
Z. Ji, H. Li, D. Peterle, J. A. Paulo, S. B. Ficarro, T. E. Wales, J. Marto, S. Gygi, J. R. Engen, T. A. Rapoport
This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.
bioRxiv · Oct 21, 2021Biochemistry
P. Wei, A. J. Bott, A. A. Cluntun, J. T. Morgan, C. N. Cunningham, J. C. Schell, Y. Ouyang, S. B. Ficarro, J. A. Marto, N. N. Danial, R. J. DeBerardinis, J. Rutter
This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.
bioRxiv · Aug 26, 2021 · PreprintCancer Biology
C. Dubiella, B. J. Pinch, D. Zaidman, T. D. Manz, E. Poon, S. He, E. Resnick, E. M. Langer, C. J. Daniel, H.-S. Seo, Y. Chen, S. B. Ficarro, Y. Jamin, X. Lian, S. Kibe, , N. London
Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.
bioRxiv · Mar 20, 2020 · PreprintCancer Biology
S. C. Sivakumaren, H. Shim, T. Zhang, F. M. Ferguson, M. R. Lundquist, C. M. Browne, H.-S. Seo, M. N. Paddock, T. D. Manz, B. Jiang, M.-F. Hao, P. Krishnan, D. G. Wang, T. J. Yang, N. P. Kwiatkowski, , N. S. Gray
This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.
bioRxiv · Oct 25, 2019Cancer Biology
A. A. Adhikari, T. C. Seegar, S. B. Ficarro, M. D. McCurry, D. Ramachandran, L. Yao, S. N. Chaudhari, S. Ndousse-Fetter, A. S. Banks, J. A. Marto, S. C. Blacklow, A. S. Devlin
This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.
bioRxiv · May 17, 2019Microbiology
Y. J. Joo, S. B. Ficarro, Y. Chun, J. A. Marto, S. Buratowski
The paper analyzes RNA polymerase II elongation complex dynamics in vitro using mass spectrometry, revealing changes in factor binding and phosphorylation patterns over time.
bioRxiv · Jan 2, 2019Biochemistry