P. Gautier

Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.

The paper shows that loss of primary cilia in adult mouse bile duct cells leads to cyst formation via a fibronectin-rich microenvironment and a novel cyst-fission process, which can be inhibited by targeting a specific integrin receptor.

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.