Author

A. Pennycuick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:mouse· 1

Frequent Co-Authors

S. M. Janes· 4 shared V. H. Teixeira· 3 shared C. Denais· 2 shared E. Nigro· 2 shared K. H. C. Gowers· 2 shared M. Falzon· 2 shared R. E. Hynds· 2 shared A. Akarca· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

S. M. Janes

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4 papers

Recent·Most cited

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

F. R. Millar, A. Pennycuick, M. Muir, A. Quintanilla, P. Hari, E. Freyer, P. Gautier, A. Meynert, V. H. Teixeira, J. Connelly, W. A. Wallace, A. H. Sims, M. C. Frame, L. Boulter, S. M. Janes, , J. C. Acosta

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

bioRxiv · Jun 4, 2021 · PreprintCancer Biology

BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma

Y. Ishii, K. K. Kolluri, A. Pennycuick, E. Nigro, D. Alrifai, E. Borg, M. Falzon, K. Shah, N. Kumar, S. M. Janes

This study shows BAP1 and YY1 suppress TRAIL receptor expression in MPM, making them potential targets to enhance TRAIL therapy.

bioRxiv · Aug 31, 2020Cancer Biology

Cell-intrinsic differences between human airway epithelial cells from children and adults

E. F. Maughan, R. E. Hynds, A. Pennycuick, E. Nigro, K. H. C. Gowers, C. Denais, S. Gomez-Lopez, K. A. Lazarus, J. C. Orr, D. R. Pearce, S. E. Clarke, D. D. H. Lee, M. N. J. Woodall, T. Masonou, K.-M. Case, , S. M. Janes

The paper compares airway epithelial cells from children and adults, finding intrinsic differences in transcriptional profiles and regenerative capacity.

bioRxiv · Apr 20, 2020Cell Biology

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

A. Pennycuick, V. H. Teixeira, K. AbdulJabbar, S. E. A. Raza, T. Lund, A. Akarca, R. Rosenthal, C. P. Pipinikas, H. Lee-Six, D. P. Chandrasekharan, R. E. Hynds, K. H. C. Gowers, J. Y. Henry, C. Denais, M. Falzon, , S. M. Janes

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

bioRxiv · Nov 10, 2019Cancer Biology