P. Genschik

Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage

This study shows that metabolic enzymes act as autophagy receptors in plants to degrade defense executors during viral infection, revealing autophagy as a tolerance pathway rather than an antiviral defense.

Arabidopsis AGO1 N-terminal Poly-Q domain promotes phase separation and association with stress granules during heat stress

This study shows that AGO1's Poly-Q domain enables phase separation and association with stress granules during heat stress in Arabidopsis, protecting AGO1 function without affecting small RNA activity.

Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators

The paper identifies proteasome-associated HECT-type ubiquitin ligases that relay and process hormone-specific transcriptional activators, regulating their activity and stability.

The Arabidopsis F-box protein FBW2 degrades AGO1 to avoid spurious loading of illegitimate small RNA

This study shows that FBW2 degrades AGO1 to prevent off-target RNA silencing by avoiding illegitimate small RNA loading.

Molecular features of RNA silencing against phloem-restricted polerovirus TuYV enable amplification of silencing signal from host transcripts

The paper investigates RNA silencing against TuYV in Arabidopsis, revealing 22-nt vsiRNA production by DCL2 and AGO1 stabilization despite viral suppression.

Immunocapture of dsRNA-bound proteins provides insight into tobacco rattle virus replication complexes and reveals Arabidopsis DRB2 to be a wide-spectrum antiviral effector

This paper uses immunocapture of dsRNA-bound proteins to identify Arabidopsis DRB2 as a wide-spectrum antiviral effector against multiple plant RNA viruses.

FBL17 targets CDT1a for degradation in early S-phase to prevent Arabidopsis genome instability

The paper identifies FBL17 as the E3 ligase responsible for CDT1a degradation in early S-phase of Arabidopsis, preventing genome instability.