Author

J. V. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2

Frequent Co-Authors

A. Goga· 3 shared H. S. Rugo· 2 shared J. Winkler· 2 shared A. Abbasi· 1 shared A. Detweiler· 1 shared A. N. Goga· 1 shared A. Nanjaraj· 1 shared A. O. Pisco· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

A. Goga

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Stability of navigation in catheter-based endovascular procedures

C. M. Hartquist, J. V. Lee, M. Y. Qiu, C. Suskin, V. Chandrasekaran, H. R. Lowe, M. A. Zayed, J. W. Osbun, G. M. Genin

The paper identifies catheter herniation as a bifurcation phenomenon and presents a mathematical stability criterion to predict and prevent it using mechanical and imaging data.

bioRxiv · Jun 2, 2023 · PreprintBioengineering

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

J. Winkler, W. Tan, C. M. M. Diadhiou, C. S. McGinnis, A. Abbasi, S. Hasnain, S. Durney, E. Atamaniuc, D. Superville, L. Awni, J. V. Lee, J. H. Hinrichs, M. Y. Hein, M. Borja, A. Detweiler, , Z. Werb

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

bioRxiv · Aug 4, 2022 · PreprintCancer Biology

A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

P. Spanogiannopoulos, T. S. Kyaw, B. G. H. Guthrie, P. H. Bradley, J. V. Lee, J. Melamed, Y. N. A. Malig, K. N. Lam, D. Gempis, M. Sandy, W. Kidder, E. L. van Blarigan, C. Atreya, A. Venook, R. R. Gerona, , P. Turnbaugh

The paper shows that a conserved enzyme in gut bacteria inactivates anticancer drugs, reducing their efficacy in mice and highlighting microbial contributions to drug metabolism.

bioRxiv · May 2, 2022 · PreprintMicrobiology

Combinatorial immunotherapies overcome MYC-driven immune evasion

J. V. Lee, F. Houseley, C. Yau, D. Van de Mark, R. Nakagawa, G. Hemmati, G. A. Hernandez, J. Winkler, Y. Zhang, S. Samson, C. Baas, L. J. Esserman, L. J. Van't Veer, H. S. Rugo, M. Matloubian, A. Goga

This study shows that MYC-driven immune evasion in TNBC can be reversed by combining immunotherapies, leading to tumor regression in mice.

bioRxiv · May 7, 2021Cancer Biology

In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer

M. C. Madonna, J. E. Duer, J. V. Lee, J. Williams, B. Avsaroglu, C. Zhu, R. Deutsch, R. Wang, B. Crouch, M. Hirschey, A. Goga, N. Ramanujam

This study develops an in vivo optical imaging method to quantify long-chain fatty acid uptake in breast cancer models, showing reduced uptake with MYC downregulation and increased uptake with tumor aggressiveness.

bioRxiv · Nov 2, 2020Bioengineering

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

K. Gnanapradeepan, S. Basu, T. Barnoud, J. I.-J. Leu, M. Good, J. V. Lee, W. J. Quinn, C.-P. Kung, R. S. Ahima, J. A. Baur, K. E. Wellen, Q. Liu, Z. T. Schug, D. L. George, M. E. Murphy

This study shows that the p53 variant Pro47Ser increases mTOR activity and metabolic efficiency in mouse and human cells through altered redox regulation of Rheb.

bioRxiv · Feb 14, 2020Cancer Biology