Author

K. N. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. Spanogiannopoulos· 2 shared A. M. Weakley· 1 shared A. N. Goga· 1 shared A. Venook· 1 shared B. G. H. Guthrie· 1 shared C. Atreya· 1 shared D. Gempis· 1 shared E. L. van Blarigan· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

P. Spanogiannopoulos

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Author profile →

2 papers

Recent·Most cited

A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

P. Spanogiannopoulos, T. S. Kyaw, B. G. H. Guthrie, P. H. Bradley, J. V. Lee, J. Melamed, Y. N. A. Malig, K. N. Lam, D. Gempis, M. Sandy, W. Kidder, E. L. van Blarigan, C. Atreya, A. Venook, R. R. Gerona, , P. Turnbaugh

The paper shows that a conserved enzyme in gut bacteria inactivates anticancer drugs, reducing their efficacy in mice and highlighting microbial contributions to drug metabolism.

bioRxiv · May 2, 2022 · PreprintMicrobiology

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

K. N. Lam, P. Spanogiannopoulos, P. Soto-Perez, M. Alexander, M. J. Nalley, J. E. Bisanz, R. R. Nayak, A. M. Weakley, F. B. Yu, P. J. Turnbaugh

This study uses phage-delivered CRISPR-Cas9 to deplete specific E. coli strains and induce genomic deletions in the gut microbiome of mice.

Cell Reports · Nov 1, 2021Peer-reviewedMicrobiology