Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
A. Kowalski, C. Betzer, S. T. Larsen, E. Gregersen, E. A. Newcombe, M. C. Bermejo, A. E. Langkilde, B. B. Kragelund, P. H. Jensen, P. Nissen
This study shows that monomeric α-synuclein activates the plasma membrane calcium pump (PMCA) in neurons, enhancing calcium expulsion through interactions with acidic phospholipids and membrane anchoring.
bioRxiv · Feb 21, 2022Biochemistry