D. Accili

Calorie Restriction activates a gastric Notch-FOXO1 pathway to expand Ghrelin cells

This study shows calorie restriction increases gastric ghrelin cells via a Notch-FOXO1 pathway, involving stem cell proliferation and differentiation changes.

Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

This study shows that Foxo1 inhibitors reduce blood glucose and generate gut β-like cells in diabetic mice, suggesting they could be an alternative to insulin.

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

Systemic benefits of Gc inhibition to preserve insulin sensitivity

This study shows that inhibiting Gc improves insulin sensitivity and beta-cell function in mice, preventing weight gain and hyperglycemia on a high-fat diet.

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactionsin beta-cell function

The paper investigates the antagonistic epistasis between Hnf4a and FoxO1 networks in beta-cell function through enhancer interactions and gene expression analysis.

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes

The paper identifies AFF3 and BACH2 as master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes using single-cell analysis of human islets.