Author

P. K. Darcy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Kearny· 1 shared D. Meyran· 1 shared F. MacKay· 1 shared F. Wiede· 1 shared G. Dodd· 1 shared J. Oliaro· 1 shared J. Waithman· 1 shared K. Hochheiser· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

C. Kearny

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2 papers

Recent·Most cited

Tissue remodeling and cell signaling underpin changes in tumor microenvironment heterogeneity in glioma oncogenesis

M. Dinevska, S. S. Widodo, L. Furst, L. Cuzcano, Y. Fang, S. Mangiola, P. J. Neeson, P. K. Darcy, R. G. Ramsay, F. MacKay, S. S. Stylli, T. Mantamadiotis

The paper shows that glioma progression involves changes in immune cell infiltration, extracellular matrix deposition, and signaling heterogeneity, with implications for therapy.

bioRxiv · Dec 5, 2021Cancer Biology

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

F. Wiede, K.-H. Lu, X. Du, S. Liang, K. Hochheiser, G. Dodd, P. Goh, C. Kearny, D. Meyran, P. Beavis, M. Henderson, S. L. Park, J. Waithman, S. Zhang, Z.-Y. Zhang, , T. Tiganis

This study shows that deleting PTPN2 in T cells improves anti-tumour immunity and CAR T cell effectiveness against solid tumours.

bioRxiv · Sep 5, 2019Immunology