The paper develops a risk score using preoperative serum biomarkers CA125, CEA, and AFP to predict progression-free and overall survival in endometrial cancer patients, validated with nomograms.

bioRxiv · Jan 23, 2024 · PreprintCancer Biology

The triose phosphate/phosphate translocator exports photosynthetic glyceraldehyde 3-phosphate from chloroplasts to trigger antimicrobial immunity in plants.

D.-P. Zuo, B. Wang, Y.-Z. Liu, Z.-S. Chen, R.-J. Hu, M.-J. He, Z.-Y. Zhang, Y. Wang, C.-G. Han

This study identifies AtTPT as a chloroplast transporter that exports glyceraldehyde 3-phosphate to trigger antimicrobial immunity in plants.

bioRxiv · Jan 10, 2024 · PreprintPlant Biology

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

S. Liang, E. Tran, X. Du, J. Dong, H. Sudholz, H. Chen, Z. Qu, N. Huntington, J. Babon, N. Kershaw, Z.-Y. Zhang, J. Baell, F. Wiede, T. Tiganis

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

bioRxiv · Jun 16, 2023 · PreprintCancer Biology

Nitrate-dependent salt tolerance mediated by OsNLP4-OsMADS27 module

A. Alfatih, J. Zhang, Y. Song, S. Ullah Jan, Z.-S. Zhang, J.-Q. Xia, Z.-Y. Zhang, T. Nazish, J. Wu, P.-X. Zhao, C. Xiang

This study identifies the OsNLP4-OsMADS27 module as a nitrate-dependent regulator of salt tolerance in rice, showing its role in stress response and yield improvement under salt stress.

bioRxiv · Jul 8, 2022 · PreprintPlant Biology

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

Y.-f. Xu, J. Sun, X. Yu, X. Chen, M. Cui, Z. Yang, C.-h. Liu, X.-z. Yang, Y.-j. Wang, S. Zhang, C. Wang, Z.-y. Zhang, W.-d. Zhao, C.-h. Wang, Z.-l. Ji, , Y.-c. Song

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

bioRxiv · Sep 17, 2020Cell Biology

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

F. Wiede, K.-H. Lu, X. Du, S. Liang, K. Hochheiser, G. Dodd, P. Goh, C. Kearny, D. Meyran, P. Beavis, M. Henderson, S. L. Park, J. Waithman, S. Zhang, Z.-Y. Zhang, , T. Tiganis

This study shows that deleting PTPN2 in T cells improves anti-tumour immunity and CAR T cell effectiveness against solid tumours.

bioRxiv · Sep 5, 2019Immunology

Influence of miR-520e-mediated MAPK signaling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2

J.-h. Tian, W.-d. Liu, Z.-y. Zhang, L.-h. Tang, D. Li, Z.-j. Tian, S.-w. Lin, Y.-j. Li

This study shows miR-520e inhibits HBV replication and HCC cell growth by suppressing EphA2 and the MAPK pathway.

bioRxiv · Jun 7, 2018Cancer Biology