Author

T. Mantamadiotis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. Filiz· 2 shared M. Dinevska· 2 shared P. Daniel· 2 shared S. S. Stylli· 2 shared S. S. Widodo· 2 shared A. H. Kaye· 1 shared A. Korfiati· 1 shared A. Marazioti· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPathology

G. Filiz

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Author profile →

5 papers

Recent·Most cited

Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment

S. S. Widodo, M. Dinevska, L. R. Cuzcano, M. Papanicolaou, T. R. Cox, S. S. Stylli, T. Mantamadiotis

This study investigates the immune and extracellular matrix microenvironment of metastatic brain tumors using multiplex immunohistochemistry and histopathological analysis, revealing differences in ECM deposition and the presence of immunosuppressive macrophages.

bioRxiv · Aug 30, 2022Cancer Biology

Tissue remodeling and cell signaling underpin changes in tumor microenvironment heterogeneity in glioma oncogenesis

M. Dinevska, S. S. Widodo, L. Furst, L. Cuzcano, Y. Fang, S. Mangiola, P. J. Neeson, P. K. Darcy, R. G. Ramsay, F. MacKay, S. S. Stylli, T. Mantamadiotis

The paper shows that glioma progression involves changes in immune cell infiltration, extracellular matrix deposition, and signaling heterogeneity, with implications for therapy.

bioRxiv · Dec 5, 2021Cancer Biology

Immune-evasion of KRAS-mutant lung adenocarcinoma mediated by cAMP response element-binding protein

G. A. Giotopoulou, G. Ntaliarda, A. Marazioti, I. Lilis, F. Kalogianni, E. Tourkochristou, N. Spiropoulou, I. Giopanou, M. Spella, M. Iliopoulou, A. Korfiati, T. Mantamadiotis, C. Rosero, T. Goldmann, S. Marwitz, G. T. Stathopoulos

This study identifies CREB-mediated immune evasion in KRAS-mutant lung adenocarcinoma by suppressing neutrophil recruitment through CXCR1 signaling.

bioRxiv · Jun 19, 2021 · PreprintCancer Biology

Intratumoral MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissuecorrelates with selective CREB signaling and specific functional gene signatures

P. Daniel, G. Filiz, M. Tymms, R. Ramsay, A. H. Kaye, S. Stylli, T. Mantamadiotis

The paper identifies intratumoral heterogeneity in glioblastoma by analyzing MAPK and PI3K pathway activation and their correlation with CREB signaling and gene signatures.

bioRxiv · Apr 20, 2018Pathology

PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

P. Daniel, G. Filiz, D. Brown, M. Christie, P. Waring, Y. Zhang, J. Haynes, C. Pouton, D. Flanagan, E. Vincan, T. Johns, K. Montgomery, W. Phillips, T. Mantamadiotis

This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.

bioRxiv · May 30, 2017Cancer Biology