Author

L. McCaffrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

S. Al Habyan· 2 shared A. Ali Abd El-Hafeez· 1 shared A. Erickson· 1 shared A. Jette· 1 shared A. Lazaris· 1 shared A. Meunier· 1 shared A. Ng· 1 shared A. Pickard· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

S. Al Habyan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer

A. Meunier, J. A. Hernandez-Castro, N. Chahley, L. Communal, S. Kheireddine, N. Koushki, N. Davoudvandi, S. Al Habyan, B. Peant, A. Lazaris, A. Ng, T. Veres, L. McCaffrey, D. Provencher, P. Metrakos, , D. Juncker

This study introduces gravity-based microfiltration to isolate CTC clusters, finding they are prevalent in ovarian and colorectal cancer patients.

bioRxiv · Dec 5, 2023Bioengineering

IRF7 impacts on prostate cancer cell survival in response to radiation

A. Pickard, F. Amoroso, K. McCulloch, A. Erickson, A. Sachdeva, R. Steele, D. Mukherjee, M. Dellett, J. McComb, L. McCaffrey, C. Hart, M. Brown, S. S. McDade, D. Waugh, N. Clarke, , I. Mills

This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.

bioRxiv · Sep 23, 2022 · PreprintCancer Biology

Evolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates

J. Ear, A. Ali Abd El-Hafeez, S. Roy, T. Ngo, N. Rajapakse, J. Choi, S. Khandelwal, M. Ghassemian, L. McCaffrey, I. Kufareva, D. Sahoo, P. Ghosh

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

bioRxiv · Sep 28, 2020 · PreprintBiochemistry

Mapping cellular-scale internal stiffness in 3D tissues with smart material hydrogel probes

S. Mok, S. Al Habyan, C. Ledoux, W. Lee, K. MacDonald, L. McCaffrey, C. Moraes

The paper develops smart material microgels to measure cellular-scale stiffness in 3D tissues and identifies high stiffness regions in cancer spheroids and tumors.

bioRxiv · Nov 15, 2019Biophysics

Girdin is a component of the lateral polarity protein network restricting cell dissemination

C. Biehler, L.-T. Wang, M. Sevigny, A. Jette, C. L. Gamblin, R. Catterall, E. Houssin, L. McCaffrey, P. Laprise

This study identifies GIRDIN as a regulator of epithelial cell polarity that restricts cell dissemination and is associated with poor cancer survival.

bioRxiv · Aug 14, 2019Cell Biology