Author
R. Deng
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2021-2023 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 30 mutual co-author links8 papers
Recent·Most cited
Stanniocalcin 2 (STC2) is a potent biomarker of hepatocellular carcinoma with its expression being augmented in Nrf1α-deficient cells, but diminished in Nrf2-deficient cells
Q. Bu, Y. Deng, Q. Wang, R. Deng, S. Hu, Z. Pei, Y. Zhang
The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.
bioRxiv · May 15, 2023 · PreprintCell Biology
Clostridium butyricum and Clostridium tyrobutyricum: angle or devil for Necrotizing enterocolitis?
Z. H. Wei, R. Tao, G. F. Zong, Y. H. Pan, H. X. Li, P. Chen, R. Deng, W. Chen, A. Wang, S. S. Xia, W. B. Tang, Y. Lu
This study compares the effects of Clostridium butyricum and Clostridium tyrobutyricum on Necrotizing enterocolitis in mice, finding that C. tyrobutyricum alleviates inflammation and improves intestinal barrier integrity, while C. butyricum worsens these conditions.
bioRxiv · Apr 10, 2023 · PreprintMicrobiology
SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair
J. He, Y. Guo, R. Deng, L. Li, C. Huang, R. Chen, Y. Wang, J. Huang, J. Cheng, G.-Q. Chen, J. Zheng, X. Zhao, J. Yu
This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.
bioRxiv · Feb 6, 2023 · PreprintCell Biology
Regulation of protein translation by TRIM21
H. Li, S. Liu, Q. Feng, R. Deng, J. Wang, X. Wang, R. Tian, Y. Xu, S. Chen, Q. Liu, L. Wang, X. Li, M. Wang, Y. Peng, S. Tang, , H. Zhu
This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.
bioRxiv · Jun 7, 2022 · PreprintImmunology
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species (ROS) in human hepatoma cells, which is alleviated by 2-bromopalmitate
R. Deng, Z. Zheng, S. Hu, M. Wang, J. Feng, P. Mattjus, Z. Zhang, Y. Zhang
This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.
bioRxiv · Sep 29, 2021Cancer Biology
Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth
C. Wang, X. Li, C. Yu, L. Wang, R. Deng, H. Liu, Z. Chen, Y. Zhang, S. Fan, H. Sun, H. Zhu, J. Wang, S. Tang
This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.
bioRxiv · Mar 11, 2021 · PreprintImmunology
Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma
A. Kapelanski-Lamoureux, Z. Chen, Z.-h. Gao, R. Deng, A. Lazaris, C. Lebeaupin, L. Giles, J. Malhotra, J. Yong, C. Zou, Y. P. de Jong, P. Metrakos, R. W. Herzog, R. J. Kaufman
This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.
bioRxiv · Jan 19, 2021Cancer Biology