Author

P. Middendorf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Sprenger· 2 shared S. Falke· 2 shared S. Guenther· 2 shared A. Kiene· 1 shared A. Luana C Barra· 1 shared B. Alves Franca· 1 shared B. Klopprogge· 1 shared C. Ehrt· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. Sprenger

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Author profile →

2 papers

Recent·Most cited

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

V. Kremling, S. Falke, Y. Fernandez-Garcia, C. Ehrt, A. Kiene, B. Klopprogge, T. E. S. Scheer, F. Barthels, P. Middendorf, S. Kuehn, S. Guenther, M. Rarey, H. N. Chapman, D. Oberthuer, J. Sprenger

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

bioRxiv · Mar 13, 2024 · PreprintBiochemistry

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

V. Srinivasan, H. Brognaro, P. R. Prabhu, E. E. de Souza, S. Guenther, P. Y. A. Reinke, T. J. Lane, H. Ginn, H. Han, W. Ewert, J. Sprenger, F. H. M. Koua, S. Falke, N. Werner, H. Andaleeb, , P

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

Communications Biology · Aug 11, 2022Peer-reviewedBiochemistry