Author

G. J. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

W. D. Rawlinson· 3 shared A. Kelleher· 2 shared S. G. Turville· 2 shared A. Abayasingam· 1 shared A. Aggarwal· 1 shared A. Akerman· 1 shared A. Chitsazan· 1 shared A. D. Kelleher· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

W. D. Rawlinson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution

C. S. P. Foster, G. J. Walker, T. Jean, M. Wong, L. Brassil, S. Isaacs, Y. Lu, S. G. Turville, A. Kelleher, W. D. Rawlinson

This study tracks SARS-CoV-2 evolution through 33-100 serial passages in vitro, identifying convergent mutations that may confer fitness or transmissibility advantages.

bioRxiv · Nov 2, 2023Evolutionary Biology

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

A. Aggarwal, C. Fichter, V. Milogiannakis, T. Ison, M. Ruiz Silva, C. Esneau, N. Bartlett, L. Burrell, S. Patel, M. Churchill, T. Angelovich, R. Parry, J. D. Sng, G. G. Neely, C. L. Moreno, , S. G. Turville

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

bioRxiv · Dec 14, 2020Immunology

Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

G. J. Walker, B. Ferguson, H. Handoko, P. Mukhopadhyay, A. Chitsazan, L. Balmer, G. Morahan

The paper identifies different genetic mechanisms underlying spontaneous versus UVR-induced melanoma in mice using the collaborative cross genetic resource.

bioRxiv · Oct 16, 2018Cancer Biology