Author

J.-A. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. J. Boyle· 5 shared B. D. Wines· 3 shared D. R. Drew· 3 shared J. G. Beeson· 3 shared M. Hogarth· 3 shared A. SheelaNair· 2 shared C. Engwerda· 2 shared D. Andrew· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersImmunology

M. J. Boyle

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6 papers

Recent·Most cited

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

R. Mukhiya, W. A. Fleischmann, J. R. Loughland, J.-A. Chan, F. de Labastida Rivera, D. Andrew, J. G. Beeson, J. S. McCarthy, B. Barber, J. A. Lopez, C. Engwerda, R. Thomson-Luque, M. J. Boyle

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

bioRxiv · Apr 28, 2024Immunology

Age dependent changes in circulating Tfh cells influence the development of functional antibodies to malaria in children.

J.-A. Chan, J. Loughland, L. de la Parte, S. Okano, I. Ssewanyana, M. Nalubega, F. Nankya, K. Musinguzi, J. Rek, E. Arinaitwe, P. Tipping, P. Bourke, D. Andrew, N. Dooley, A. SheelaNair, , M. J. Boyle

The paper examines age-related changes in Tfh cells and their impact on antibody development against malaria in children, finding age-dependent shifts in Tfh cell subsets and antibody responses.

bioRxiv · Dec 12, 2021Immunology

Novel virus-like particle vaccine encoding the circumsporozoite protein of Plasmodium falciparum is immunogenic and induces functional antibody responses

L. Kurtovic, D. Wetzel, L. Reiling, D. R. Drew, C. Palmer, B. Kouskousis, E. Hanssen, B. D. Wines, P. M. Hogarth, M. Suckow, V. Jenzelewski, M. Piontek, J.-A. Chan, J. Beeson

This paper describes a novel virus-like particle vaccine using duck hepatitis B virus surface antigen to display Plasmodium falciparum CSP, showing improved immunogenicity and functional antibody responses in mice.

bioRxiv · Dec 14, 2020Immunology

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

J.-A. Chan, F. de Labastida Rivera, J. Loughland, J. A. Engel, H. J. Lee, A. SheelaNair, B. Wines, F. Amante, L. Webb, P. Mukhopadhyay, A.-M. Patch, M. Hogarth, J. A. Beeson, J. McCarthy, A. Haque, , M. J. Boyle

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

bioRxiv · May 18, 2020Immunology

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial

L. Kurtovic, T. Atre, G. Feng, B. D. Wines, J.-A. Chan, M. J. Boyle, D. R. Drew, M. Hogarth, F. J. I. Fowkes, E. S. Bergmann-Leitner, J. G. Beeson

This study shows RTS,S malaria vaccine induces functional anti-CSP antibodies associated with reduced parasitemia after challenge.

bioRxiv · Nov 22, 2019Immunology

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

J.-A. Chan, D. Wetzel, L. Reiling, K. Miura, D. R. Drew, P. R. Gilson, D. A. Anderson, J. S. Richards, C. A. Long, M. Suckow, V. Jenzelewski, T. Tsuboi, M. J. Boyle, M. Piontek, J. G. Beeson

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.

bioRxiv · Aug 5, 2019Immunology