Author

M. J. Boyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 7

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J.-A. Chan· 5 shared D. Andrew· 4 shared A. SheelaNair· 3 shared B. Barber· 3 shared C. Engwerda· 3 shared J. A. Lopez· 3 shared J. G. Beeson· 3 shared J. Loughland· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

J.-A. Chan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

R. Mukhiya, W. A. Fleischmann, J. R. Loughland, J.-A. Chan, F. de Labastida Rivera, D. Andrew, J. G. Beeson, J. S. McCarthy, B. Barber, J. A. Lopez, C. Engwerda, R. Thomson-Luque, M. J. Boyle

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

bioRxiv · Apr 28, 2024Immunology

Malaria drives unique regulatory responses across multiple immune cell subsets

N. L. Dooley, Z. Pava, J. R. Loughland, J. Hamelink, K. Berry, D. Andrew, M. S. F. Soon, A. SheelaNair, K. A. Piera, T. William, B. Barber, M. J. Grigg, C. R. Engwerda, J. A. Lopez, N. M. Anstey, M. J. Boyle

The paper analyzes single-cell RNA sequencing data from malaria patients to identify immunoregulatory responses in specific immune cell subsets during infection and recovery.

bioRxiv · Nov 16, 2022 · PreprintImmunology

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

Y. Wang, F. Rivera, C. Edwards, T. Frame, J. A. Engel, L. Bukali, J. Na, S. Ng, D. Corvino, M. Montes de Oca, P. Bunn, M. Soon, D. Andrew, J. Loughland, F. Amante, , C. Engwerda

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

bioRxiv · Sep 4, 2022Immunology

Age dependent changes in circulating Tfh cells influence the development of functional antibodies to malaria in children.

J.-A. Chan, J. Loughland, L. de la Parte, S. Okano, I. Ssewanyana, M. Nalubega, F. Nankya, K. Musinguzi, J. Rek, E. Arinaitwe, P. Tipping, P. Bourke, D. Andrew, N. Dooley, A. SheelaNair, , M. J. Boyle

The paper examines age-related changes in Tfh cells and their impact on antibody development against malaria in children, finding age-dependent shifts in Tfh cell subsets and antibody responses.

bioRxiv · Dec 12, 2021Immunology

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

J.-A. Chan, F. de Labastida Rivera, J. Loughland, J. A. Engel, H. J. Lee, A. SheelaNair, B. Wines, F. Amante, L. Webb, P. Mukhopadhyay, A.-M. Patch, M. Hogarth, J. A. Beeson, J. McCarthy, A. Haque, , M. J. Boyle

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

bioRxiv · May 18, 2020Immunology

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial

L. Kurtovic, T. Atre, G. Feng, B. D. Wines, J.-A. Chan, M. J. Boyle, D. R. Drew, M. Hogarth, F. J. I. Fowkes, E. S. Bergmann-Leitner, J. G. Beeson

This study shows RTS,S malaria vaccine induces functional anti-CSP antibodies associated with reduced parasitemia after challenge.

bioRxiv · Nov 22, 2019Immunology

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

J.-A. Chan, D. Wetzel, L. Reiling, K. Miura, D. R. Drew, P. R. Gilson, D. A. Anderson, J. S. Richards, C. A. Long, M. Suckow, V. Jenzelewski, T. Tsuboi, M. J. Boyle, M. Piontek, J. G. Beeson

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.

bioRxiv · Aug 5, 2019Immunology