Author

J. Loughland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

M. J. Boyle· 3 shared A. SheelaNair· 2 shared C. Engwerda· 2 shared D. Andrew· 2 shared F. Amante· 2 shared J. A. Engel· 2 shared J.-A. Chan· 2 shared M. Hogarth· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

M. J. Boyle

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Author profile →

3 papers

Recent·Most cited

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

Y. Wang, F. Rivera, C. Edwards, T. Frame, J. A. Engel, L. Bukali, J. Na, S. Ng, D. Corvino, M. Montes de Oca, P. Bunn, M. Soon, D. Andrew, J. Loughland, F. Amante, , C. Engwerda

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

bioRxiv · Sep 4, 2022Immunology

Age dependent changes in circulating Tfh cells influence the development of functional antibodies to malaria in children.

J.-A. Chan, J. Loughland, L. de la Parte, S. Okano, I. Ssewanyana, M. Nalubega, F. Nankya, K. Musinguzi, J. Rek, E. Arinaitwe, P. Tipping, P. Bourke, D. Andrew, N. Dooley, A. SheelaNair, , M. J. Boyle

The paper examines age-related changes in Tfh cells and their impact on antibody development against malaria in children, finding age-dependent shifts in Tfh cell subsets and antibody responses.

bioRxiv · Dec 12, 2021Immunology

Th2-like T-follicular helper cells promote functional antibody production during Plasmodium falciparum infection

J.-A. Chan, F. de Labastida Rivera, J. Loughland, J. A. Engel, H. J. Lee, A. SheelaNair, B. Wines, F. Amante, L. Webb, P. Mukhopadhyay, A.-M. Patch, M. Hogarth, J. A. Beeson, J. McCarthy, A. Haque, , M. J. Boyle

The paper identifies Th2-like T-follicular helper cells as key drivers of functional antibody production during Plasmodium falciparum infection, suggesting they are targets for improved malaria vaccines.

bioRxiv · May 18, 2020Immunology