Author

K. W. East

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

G. P. Lisi· 4 shared V. S. Batista· 3 shared G. Palermo· 2 shared U. N. Morzan· 2 shared A. Acharya· 1 shared A. Ayala· 1 shared A. Leith· 1 shared A. M. Fredericks· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

G. P. Lisi

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Author profile →

4 papers

Recent·Most cited

Identification and Mechanistic Basis of non-ACE2 Blocking Neutralizing Antibodies from COVID-19 Patients with Deep RNA Sequencing and Molecular Dynamics Simulations

A. M. Fredericks, K. W. East, Y. Shi, J. Liu, F. Maschietto, A. Ayala, W. G. Cioffi, M. Cohen, W. G. Fairbrother, C. T. Lefort, G. J. Nau, M. M. Levy, J. Wang, V. S. Batista, G. P. Lisi, S. F. Monaghan

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

bioRxiv · Jun 29, 2022Immunology

Enhanced Specificity Mutations Perturb Allosteric Signaling in CRISPR-Cas9

G. Palermo, L. Nierzwicki, K. W. East, U. N. Morzan, P. R. Arantes, G. P. Lisi, V. S. Batista

The paper investigates how specificity-enhancing mutations in CRISPR-Cas9 affect allosteric signaling, showing that mutations like K855A disrupt the HNH domain structure and signaling transfer more than others.

bioRxiv · Sep 14, 2021Biophysics

Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics

K. W. East, J. C. Newton, U. N. Morzan, A. Acharya, E. Skeens, G. Jogl, V. S. Batista, G. Palermo, G. P. Lisi

This study uses NMR and GaMD simulations to investigate allosteric motions in the CRISPR-Cas9 HNH nuclease, revealing a dynamic pathway involved in DNA cleavage activation.

bioRxiv · Oct 10, 2019Biophysics

NMRdock: Lightweight and Modular NMR Processing

K. W. East, A. Leith, A. Ragavendran, F. Delaglio, G. P. Lisi

NMRdock provides a containerized solution for NMR data processing to reduce complexity and improve accessibility for newcomers and maintainability of software.

bioRxiv · Jun 25, 2019 · PreprintBiophysics