Author

V. S. Batista

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

G. P. Lisi· 3 shared K. W. East· 3 shared G. Palermo· 2 shared J. Wang· 2 shared U. N. Morzan· 2 shared A. Acharya· 1 shared A. Ayala· 1 shared A. M. Fredericks· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

G. P. Lisi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors

J. Wang, V. S. Batista, C. G. Bunick

This paper investigates the triple-action inhibitory mechanism of deucravacitinib on TYK2, revealing its inhibition in three distinct states and structural basis for selectivity.

bioRxiv · Oct 9, 2023Biochemistry

Identification and Mechanistic Basis of non-ACE2 Blocking Neutralizing Antibodies from COVID-19 Patients with Deep RNA Sequencing and Molecular Dynamics Simulations

A. M. Fredericks, K. W. East, Y. Shi, J. Liu, F. Maschietto, A. Ayala, W. G. Cioffi, M. Cohen, W. G. Fairbrother, C. T. Lefort, G. J. Nau, M. M. Levy, J. Wang, V. S. Batista, G. P. Lisi, S. F. Monaghan

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

bioRxiv · Jun 29, 2022Immunology

Enhanced Specificity Mutations Perturb Allosteric Signaling in CRISPR-Cas9

G. Palermo, L. Nierzwicki, K. W. East, U. N. Morzan, P. R. Arantes, G. P. Lisi, V. S. Batista

The paper investigates how specificity-enhancing mutations in CRISPR-Cas9 affect allosteric signaling, showing that mutations like K855A disrupt the HNH domain structure and signaling transfer more than others.

bioRxiv · Sep 14, 2021Biophysics

Proton egress pathway during the S1 to S2 transition of the Oxygen Evolving Complex ofPhotosystem II

D. Kaur, Y. Zhang, K. M. Reiss, M. Mandal, G. W. Brudvig, V. S. Batista, M. R. Gunner

The paper uses computational methods to analyze proton transfer pathways during the S1 to S2 transition of the Oxygen Evolving Complex in Photosystem II, identifying the broad channel as the most likely proton exit route.

bioRxiv · Jan 29, 2021 · PreprintBiophysics

Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics

K. W. East, J. C. Newton, U. N. Morzan, A. Acharya, E. Skeens, G. Jogl, V. S. Batista, G. Palermo, G. P. Lisi

This study uses NMR and GaMD simulations to investigate allosteric motions in the CRISPR-Cas9 HNH nuclease, revealing a dynamic pathway involved in DNA cleavage activation.

bioRxiv · Oct 10, 2019Biophysics

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

K. M. Knecht, O. Buzovetsky, C. Schneider, D. Thomas, V. Srikanth, F. Tofoleanu, K. Reiss, N. Ferreiros, G. Geisslinger, V. S. Batista, X. Ji, J. Cinatl, O. T. Keppler, Y. Xiong

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

bioRxiv · Apr 6, 2018Biochemistry