P. Raman

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Deletion of smooth muscle O-GlcNAc transferase prevents development of atherosclerosis in western diet-fed hyperglycemic ApoE-/- mice in vivo

This study shows that deleting smooth muscle O-GlcNAc transferase (smOGT) reduces atherosclerosis in hyperglycemic ApoE-/- mice fed a Western diet.

Recurrent but short-lived duplications of centromeric proteins in holocentric Caenorhabditis species

The paper identifies frequent gene duplications of centromeric proteins in Caenorhabditis species, showing short-term retention and subsequent degeneration.

Novel classes and evolutionary turnover of histone H2B variants in the mammalian germline

This study identifies two new H2B variants in mammals and shows their expression in the germline, suggesting roles in chromatin packaging or non-chromatin functions.

MYC controls metastatic heterogeneity in pancreatic cancer

This study identifies MYC as a key driver of metastatic heterogeneity in pancreatic cancer by linking its activity to increased metastasis through TAM recruitment.

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

The paper uses single-cell and bulk RNA sequencing to study macrophage heterogeneity in medulloblastoma and shows differential recruitment with targeted vs. radiation therapy.

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.