Author

J. L. Rokita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:deep learning· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. C. Resnick· 3 shared B. Zhang· 3 shared D. Martinez· 3 shared H. Ijaz· 3 shared J. M. Maris· 3 shared K. A. Cole· 3 shared K. R. Bosse· 3 shared K. S. Gaonkar· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

A. C. Resnick

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7 papers

Recent·Most cited

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

A. K. Weiner, A. B. Radaoui, M. Tsang, D. Martinez, S. Sidoli, K. L. Conkrite, A. Delaidelli, A. Modi, J. L. Rokita, K. Patel, M. V. Lane, B. Zhang, C. Zhong, B. Ennis, D. P. Miller, , S. J. Diskin

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

The Children's Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science

J. V. Lilly, J. L. Rokita, J. L. Mason, T. Patton, S. Stefankiewiz, D. Higgins, G. Trooskin, C. A. Larouci, K. Arya, E. Appert, A. P. Heath, Y. Zhu, M. A. Brown, B. Zhang, B. K. Farrow, , W. Rife

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

bioRxiv · Oct 14, 2022Cancer Biology

ALT in Pediatric High-Grade Gliomas Can Occur without ATRX Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants

J. L. Stundon, H. Ijaz, K. S. Gaonkar, R. S. Kaufman, R. Jin, A. Karras, Z. Vaksman, J. Kim, R. J. Corbett, M. R. Lueder, D. P. Miller, Y. Guo, M. Santi, M. Li, G. Lopez, , K. A. Cole

This paper identifies ALT in pediatric high-grade gliomas without ATRX mutations and links it to germline MMR variants.

bioRxiv · Aug 5, 2022 · PreprintCancer Biology

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

J. B. Foster, C. Griffin, J. L. Rokita, A. Stern, C. Brimley, K. Rathi, M. V. Lane, S. N. Buongervino, T. Smith, P. J. Madsen, D. Martinez, R. Wechsler-Reya, K. Kariko, P. B. Storm, D. M. Barrett, , K. R. Bosse

This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.

bioRxiv · Jul 6, 2021Cancer Biology

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

M. T. Dang, M. Gonzalez, K. S. Gaonkar, K. S. Rathi, P. Young, S. Arif, L. Zhai, M. Alam, S. Devalaraja, T. Tsun, I. Folkert, P. Raman, J. L. Rokita, D. Martinez, J. Taroni, , M. Haldar

The paper uses single-cell and bulk RNA sequencing to study macrophage heterogeneity in medulloblastoma and shows differential recruitment with targeted vs. radiation therapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology

LIN28B-PDZ Binding Kinase Signaling Promotes Neuroblastoma Metastasis

D. Chen, J. Cox, J. Annam, M. Weingart, G. Essien, K. S. Rathi, J. L. Rokita, P. Khurana, S. M. Cuya, K. R. Bosse, A. Pilgrim, D. Li, J. M. Maris, R. W. Schnepp

This study identifies LIN28B's role in promoting neuroblastoma metastasis through the regulation of PBK, a kinase that enhances self-renewal and migration.

bioRxiv · Aug 21, 2019Cancer Biology

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)

H. Ijaz, M. P. Koptyra, K. S. Gaonkar, J. L. Rokita, V. P. Baubet, L. Tauhid, Y. Zhu, M. A. Brown, G. Lopez Garcia, B. Zhang, S. J. Diskin, Z. Vaksman, J. L. Mason, E. M. Appert, J. V. Lilly, , K. A. Cole

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

bioRxiv · May 31, 2019Cancer Biology