J. M. Young

Widespread fungal-bacterial competition for magnesium enhances antibiotic resistance

Fungi sequester magnesium from bacteria, reducing their fitness but increasing antibiotic resistance to colistin.

Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression

This paper shows that MEK1/2 inhibitors reduce MmuPV1 replication and promote tumor regression in mice, suggesting MEK1/2 as a therapeutic target for papillomavirus diseases.

Novel classes and evolutionary turnover of histone H2B variants in the mammalian germline

This study identifies two new H2B variants in mammals and shows their expression in the germline, suggesting roles in chromatin packaging or non-chromatin functions.

Rare genera differentiate urban green space soil bacterial communities in three cities across the world

The paper examines the relationship between vegetation complexity and soil bacterial communities in urban green spaces across three cities, finding that rare genera significantly differ between vegetation complexity categories.

A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

The paper identifies a natural variant of MMS21 that restricts 2-micron plasmids in S. cerevisiae by increasing plasmid instability through a single amino acid change.

Hybridization promotes asexual reproduction in Caenorhabditis nematodes

This paper investigates how hybridization between two Caenorhabditis nematode species leads to asexual reproduction through altered meiosis and genome inheritance.

Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins

The paper uses combinatorial mutagenesis to generate super-restrictor antiviral proteins against Thogoto virus, finding variants with enhanced restriction activity compared to wild-type MxA.

Killer meiotic drive and dynamic evolution of the wtf gene family

The paper analyzes the evolution of the wtf gene family in S. pombe, showing dynamic evolution through copy number variation and recombination mechanisms involving transposons.

Mannan molecular sub-structures control nanoscale glucan exposure in Candida

This study shows that specific N-mannan features in Candida species regulate nanoscale glucan exposure, impacting immune recognition.

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals

This study investigates the evolutionary origins and diversification of testis-specific short H2A histone variants in mammals, identifying a novel variant and tracing their lineage-specific evolution.