Author

P. S. Ganapathy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Li· 7 shared S. Herberg· 7 shared A. Singh· 4 shared T. Bague· 4 shared W. D. Stamer· 4 shared A. Kirschner· 3 shared A. N. Strat· 3 shared H. Yoo· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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7 shared papersCell Biology

H. Li

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology

H. Li, M. Kuhn, R. A. Kelly, A. Singh, K. K. Palanivel, I. Salama, M. L. De Ieso, W. D. Stamer, P. S. Ganapathy, S. Herberg

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.

bioRxiv · Sep 8, 2023 · PreprintCell Biology

YAP/TAZ inactivation with simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction

H. Yoo, A. Singh, H. Li, A. N. Strat, T. Bague, P. S. Ganapathy, S. Herberg

This study shows that simvastatin reduces YAP/TAZ activity and ECM dysfunction in glucocorticoid-treated human trabecular meshwork cells.

bioRxiv · Sep 27, 2022 · PreprintCell Biology

YAP/TAZ mediate TGFβ2-induced Schlemm's canal cell dysfunction

H. Li, A. Singh, K. M. Perkumas, W. D. Stamer, P. S. Ganapathy, S. Herberg

This study shows that YAP/TAZ signaling is involved in TGFβ2-induced dysfunction of Schlemm's canal cells and that inhibiting YAP/TAZ can reduce this dysfunction.

bioRxiv · Jun 6, 2022Cell Biology

Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior in response to glaucomatous insult

A. N. Strat, A. Kirschner, H. Yoo, A. Singh, T. Bague, H. N. Li, S. Herberg, P. S. Ganapathy

This study develops a 3D hydrogel system to mimic the in vivo mouse optic nerve head astrocyte microenvironment and assesses their reactivity to TGFβ2 treatment.

bioRxiv · Jan 8, 2022 · PreprintBioengineering

Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells

H. Li, V. Raghunathan, W. D. Stamer, P. S. Ganapathy, S. Herberg

This study shows that ECM stiffness and TGFβ2 regulate YAP/TAZ activity in HTM cells, contributing to glaucoma progression.

bioRxiv · Sep 29, 2021Cell Biology

TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

H. Li, J. L. Henty-Ridilla, P. S. Ganapathy, S. S. Herberg

This study shows TGFβ2 increases HTM cell contractility via ERK and ROCK pathways, with distinct crosstalk depending on the culture substrate.

bioRxiv · Jul 1, 2021Cell Biology

Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes.

A. Kirschner, A. N. Strat, J. Yablonski, T. Bague, H. Li, S. Herberg, P. S. Ganapathy

This study shows that inhibiting mechanosensitive channels reduces TGFβ2-induced actin remodeling and reactivity in optic nerve head astrocytes.

bioRxiv · Jun 5, 2021Cell Biology

A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling

H. Li, T. Bague, A. Kirschner, R. W. Weisenthal, A. E. Patteson, N. Annabi, W. D. Stamer, P. S. Ganapathy, S. Herberg

This paper develops a biomimetic HTM hydrogel model to study glaucoma pathology and test therapeutic interventions.

bioRxiv · Jul 31, 2020Bioengineering