A. E. Patteson

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.

Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

Bacteria colonies modify their shear and compressive mechanical properties in response to different growth substrates

This study shows bacteria colonies adjust their mechanical properties based on agar substrate concentration through shear and compressive rheology measurements.

Stochastic bounds of aggregation dynamics distinguish near-wild-type from wild-type strains in social bacteria

The paper identifies subtle genetic effects on developmental dynamics in Myxococcus xanthus by analyzing stochastic aggregation patterns.

Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation.

This study shows vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation in mouse embryonic fibroblasts.

How cells wrap around virus-like particles using extracellular filamentous protein structures

The paper constructs a computational model to study how filamentous extracellular components affect viral wrapping during endocytosis, finding optimal densities enhance infection efficiency.

Extracellular vimentin is sufficient to promote cell attachment, spreading, and motility by a mechanism involving N-acetyl glucosamine-containing structures

This study shows extracellular vimentin promotes cell attachment, spreading, and motility via N-acetyl glucosamine-containing structures, identifying a novel adhesion mechanism.

Transcription regulates bleb formation and stability independent of nuclear rigidity

This study shows transcription affects nuclear bleb formation and stability independently of chromatin structure or nuclear rigidity.

Dynamic remodeling of fiber networks with stiff inclusions under compressive loading

This study investigates how stiff inclusions affect the mechanical response of fiber networks under compression, showing that they enable stiffening under load.

Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

Rab11 endosomes coordinate centrosome number and movement following mitotic exit

This study shows Rab11-endosomes regulate centrosome movement and abscission by controlling pericentrin organization in human and zebrafish cells.

The role of vimentin-nuclear interactions in persistent cell motility through confined spaces

This paper develops a model showing vimentin-null cells move faster and are more persistent in confined spaces due to reduced nuclear positioning and microtubule orientation.

How do biofilms feel their environment?

This study investigates how biofilms sense and respond to substrate stiffness using synthetic hydrogels and time-lapse microscopy, finding that biofilm growth increases with substrate stiffness.

Extracellular vimentin as a target against SARS- CoV-2 host cell invasion

The paper identifies extracellular vimentin as a potential target for preventing SARS-CoV-2 infection by showing it facilitates viral entry through interaction with the spike protein and ACE2.

A torsion-based rheometer for measuring viscoelastic material properties

This paper introduces a low-cost, portable rheometer for measuring viscoelastic properties, suitable for educational and field use.

Vimentin intermediate filaments mediate cell shape on visco-elastic substrates

This study shows vimentin enhances cell spreading on viscoelastic substrates but not elastic ones, suggesting it modulates cell mechanosensing.

Dynamic nuclear structure emerges from chromatin crosslinks and motors

The paper models how motor activity and crosslinks generate dynamic nuclear structure and chromosome motions.

A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling

This paper develops a biomimetic HTM hydrogel model to study glaucoma pathology and test therapeutic interventions.

Swarming bacterial fronts: Dynamics and morphology of active swarm interfaces propagating through passive frictional domains

The paper studies the dynamics and morphology of active-passive interfaces in swarming bacteria, finding unique surface roughness and growth exponents influenced by hydrodynamic and steric interactions.

Vimentin protects the structural integrity of the nucleus and suppresses nuclear damage caused by large deformations

This study shows that vimentin intermediate filaments protect the nucleus from damage during cell migration by maintaining its shape and mechanical integrity.

Quenching an active swarm: Effect of light exposure on collective motility in swarming Serratia marcescens colonies

This study examines how light exposure affects collective motility in swarming Serratia marcescens colonies, identifying conditions under which mobility is suppressed or reversed.

The propagation of active-passive interfaces in bacterial swarms

This study investigates how active-passive interfaces evolve in bacterial swarms, showing that their propagation is influenced by local swarm speed and curvature, analogous to classical interface theories.