M. Kuhn

Changes in anterior cingulate connectivity associated with response to antidepressant treatment for major depressive disorder

This study examines changes in anterior cingulate cortex connectivity in response to antidepressant treatment in MDD patients, finding distinct patterns associated with treatment response and remission.

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

Aging and intraocular pressure homeostasis in mice

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

Consistency across multi-omics layers in a drug-perturbed gut microbial community

The paper examines consistency and complementarity across five omics layers in a drug-perturbed gut microbial community, finding high agreement in species abundance and functional insights from different data types.

C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants

This study finds that C. difficile is often overdiagnosed in adults and is a common commensal in infants, with distinct microbial associations across age groups.

Mechanotaxis directs Pseudomonas aeruginosa twitching motility.

This study identifies mechanotaxis as the mechanism by which Pseudomonas aeruginosa directs twitching motility using the Chp system to control directional migration.

Dissecting the collateral damage of antibiotics on gut microbes

This study characterizes the antibiotic activity spectrum on gut bacteria, revealing species-specific effects and identifying antidotes to mitigate collateral damage.